They are tremendously effective against one of the bosses, though as each acid splash effectively stun-locks it while continually dealing heavy damage. However, their corrosive effect doesn't quite deal as much damage as the flame rounds, although some enemies are weaker to them, and the splash of acid has a smaller radius. They're easier to find since unlike the flame rounds, they can be crafted.

Acid Attack: Acid rounds are an option for the grenade launcher in Claire's scenario.

note Chris' has reduced focus time, Jill's draws faster, and Wesker's simply deal more damage per shot. They are noted to have been personally modified by their respective owners to enhance their performance in certain ways, and as such boast uniquely-enhanced traits compared to the bog-standard handguns used by Leon or Claire. note Chris' and Jill's for pre-ordering the standard edition, and Wesker's is exclusive to the Deluxe Edition.

Ace Custom: The three customized Beretta 92FS Brigadier, or 'Samurai Edge', pistols that players could obtain by pre-ordering various editions of the game.

For comparison, another Tyrant of that same model can withstand point-blank explosions short of an anti-tank missile.

Absurdly Sharp Claws: William can tear a Tyrant apart with his claws.

The player cannot sequence break this part if the Infinite Knife is available from the Item Box the game doesn't recognize it as a valid knife to cut the tape, the player must explore the East Wing beforehand. This is almost identical to how it played out in Resident Evil 7.

Ability Required to Proceed: When the 1st Run protagonist first enters the RPD, the switch to one of the sealed gates in the lobby is taped shut, and they can't open it without the combat knife Marvin gives them.

Ada's only sidearm is a Mauser HSc (Broom Hc). HUNK's gear beyond the Remington 870 and Desert Eagle are both Heckler & Koch made: an MP5A3 submachine gun (LE 5) and a USP9 handgun (MUP). Their 2nd Run exclusive weapons are an M1911A1 (M19) and a Ruger Blackhawk (Quickdraw Army), respectively. The MAC-11 also reappears, but with the moniker of MQ 11. On Claire's side of the armory, her old Browning Hi-Power Mark III is renamed JMB Hp3, her grenade launcher is named the GM 79, and her starting Smith & Wesson Model 38/49 is named the SLS 60.

A.K.A.-47: Leon's signature Heckler & Koch VP70 handgun is named Matilda again, while the original Remington 870 shotgun shows up as the W-870, and the Desert Eagle returns as the Lightning Hawk.

Claire gets a minigun that just seems to be lying around. 11th-Hour Superpower: The anti-tank rocket launcher returns with Leon.

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